Figure 6. Comparison of WT and OE data.

Plots showing the ratio of data from Cav-3 OE mice/those in WT mice, ± 95% confidence intervals, in sham (left) and in HF following TAC (right). The WT data have been published previously (Bryant et al., 2018a). The x axis shows the change relative to WT: an increase in Cav-3 OE mice compared to WT results in a value >1, while a decrease results in a value <1. The coloured bands delineate different groups of data that correspond to those shown in Figs. 1 (green, top) to 5 (grey, bottom). The data in red are significantly different in Cav-3 OE and WT mice (statistical analysis performed using original data).

LVVD, left ventricular volume at diastole, μl; LVVS, left ventricular volume at systole, μl; Stroke Volume ml.min-1; Ejection Fraction, %; HW:TL, heart weight to tibial length ratio, mg/mm; LW:TL, lung weight to tibial length ratio, mg/mm; Volume, pL; Cell Capacitance, pF; T-tubule Power, P₁/P₀; T-tubule Density, μm/μm³; Cav-3, caveolin-3 expression, %; JPH-2, junctophilin expression, %; Intact Capacitance, whole_-cell capacitance, pF; Intact I_Ca, whole-cell I_Ca amplitude at 0 mV, pA; Intact I_Ca Density, whole-cell I_Ca density at 0 mV, pA/pF; Surface Capacitance, surface membrane capacitance, pF; Surface I_Ca, surface membrane I_Ca amplitude at 0 mV, pA; Surface I_Ca Density, surface membrane I_Ca density at 0 mV, pA/pF; T-tubule Capacitance, t tubule membrane capacitance, pF; T-tubule I_Ca, t-tubule membrane I_Ca amplitude at 0 mV, pA; T-tubule I_Ca Density, t-tubule membrane I_Ca density, pA/pF; Ca²⁺ Latency, calcium transient latency from action potential depolarisation, ms; Ca²⁺ Heterogeneity, calcium transient heterogeneity during upstroke, ms; Ca²⁺ amplitude, Calcium transient amplitude; Ca²⁺ Time To Peak, ms.