Table 1.

Parameter definitions and values used for numerical simulations (unless specified otherwise)

Parameter	Definition		Value
λ	Monomer source rate		1500
γ	Monomer degradation rate		5
		Strain 1	Strain 2
ρ	Conversion rate of normal monomers to subunits	5	1
ω	Reconversion rate of subunits	1	1
K	Half-maximum concentration for the conversion kinetics	500	100
δ	Degradation of subunits	2	2
τ	Polymerization rate of subunits	0.1	0.2
β	Fragmentation rate of polymers	0.0003	0.1
μ	Degradation rate of polymers	0.04	0.04
x0	Nucleus size	6	6

The values are chosen arbitrarily, with magnitudes consistent with values from Masel et al. (1999), where time is expressed in days. The aggregate-associated quantities are in fibril number per volume unit