Skip to main content
. Author manuscript; available in PMC: 2019 Jul 10.
Published in final edited form as: Am J Reprod Immunol. 2019 Apr 11;81(6):e13111. doi: 10.1111/aji.13111

Figure 6. Schematic representation of NG induced enhanced HIV-1 transmission across the ecto-cervical tissues.

Figure 6.

NG infection of the epithelial surface leads to secretion of IL-1β, which induces production of epithelial CXCL10 and IL-8 upon HIV-1 infection. These cytokines being chemo-attractants for immune cells, cause migration of higher HIV-1 target CD3+ T cells to the periphery of the epithelium and the intraepithelial region which then fuels the increase in the HIV-1 replication at the sub-mucosa and consequently enhances HIV-1 transmission.