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. Author manuscript; available in PMC: 2019 May 22.
Published in final edited form as: Trends Microbiol. 2017 Nov 6;26(3):186–190. doi: 10.1016/j.tim.2017.10.004

Figure 1. Antibody-Dependent Enhancement (ADE) of Dengue and Zika Virus.

Figure 1.

ADE during a secondary heterologous Dengue virus infection has been documented in vitro, in mice, in non-human primates, and in humans playing a key role in the worsening of the clinical presentations. In contrast, ADE of Zika virus by pre-existing immunity to Dengue virus can be induced in vitro, and in immunodeficient mice. However, there is no evidence to support ADE occurring in non-human primates or in humans.