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. Author manuscript; available in PMC: 2019 Apr 29.
Published in final edited form as: Cold Spring Harb Perspect Med. 2019 Feb 1;9(2):a031534. doi: 10.1101/cshperspect.a031534

Figure 1.

Figure 1.

The activation and domain organization of Son-of-Sevenless (SOS). (A) Ras activation is coupled to the phosphorylation of tyrosine residues on cell-surface receptors. This primarily occurs through the SH2-mediated recruitment of SOS to these receptors by adaptor proteins such as Grb2. Ras activation by SOS subsequently triggers downstream signaling responses in cells. (B) Schematic representation of the various constructs of SOS discussed in this review. DH, Dbl homology; PH, Pleckstrin homology; REM, Ras exchanger motif.