Skip to main content
. Author manuscript; available in PMC: 2019 Jun 3.
Published in final edited form as: J Int Assoc Provid AIDS Care. 2019 Jan-Dec;18:2325958218821963. doi: 10.1177/2325958218821963

Table 4.

Multiple Variable Logistic Regression Analysis for Predictors of Renal Failure through 144 Weeks of ART.

Weeks of ART (Complete
Cases/Multiple Imputation)
Explanatory Variable Complete Cases
Multiple Imputation
aOR (95% CI) P Value aOR (95% CI) P Value
24 (3806/8303) Males 0.86 (0.66-1.13) .29 0.91 (0.59-1.4) .61
Age, years 1.04 (1.02-1.05) <.001 1.01 (0.97-1.05) .52
WHO stage 3 and 4 1.23 (0.96-1.59) .11 0.9 (0.49-1.64) .66
CD4 cells/mm3 ≤100 1.05 (0.8-1.38) .71 1.17 (0.58-2.36) .59
VL >10 000 copies/mL 1.3 (1-1.67) .05 0.99 (0.74-1.32) .92
HBV positive 1.22 (0.91-1.63) .19 0.95 (0.69-1.31) .74
Baseline GFR 1 (1-1) .10 1 (1-1) .68
TDF exposure 2.34 (1.75-3.13) <.001 1.47 (1.16-1.87) <.001
48 (3784/8303) Males 0.92 (0.75-1.12) .41 0.91 (0.67-1.25) .52
Age, years 1.04 (1.03-1.05) <.001 1.01 (0.96-1.06) .55
WHO stage 3 and 4 0.78 (0.64-0.96) .02 0.83 (0.64-1.09) .16
CD4 cells/mm3 ≤100 0.93 (0.76-1.13) .46 1.08 (0.77-1.51) .60
VL >10 000 copies/mL 0.88 (0.72-1.07) .19 0.88 (0.59-1.31) .45
HBV positive 1.2 (0.95-1.53) .12 1.12 (0.83-1.5) .41
Baseline GFR 1 (1-1) .12 1 (1-1) .57
TDF exposure 1.03 (0.84-1.25) .79 1.25 (0.9-1.75) .15
96 (2802/8303) Males 1.01 (0.78-1.31) .95 1.1 (0.48-2.51) .76
Age, years 1.01 (1-1.02) .14 1 (0.96-1.05) .76
WHO stage 3 and 4 0.89 (0.69-1.16) .40 0.94 (0.35-2.48) .87
CD4 cells/mm3 ≤100 1.18 (0.89-1.56) .26 1.1 (0.18-6.68) .90
VL >10 000 copies/mL 1.02 (0.79-1.34) .86 1.4 (0.66-2.97) .29
HBV positive 1.49 (1.16-1.93) <.001 0.86 (0.32-2.34) .70
Baseline GFR 1 (1-1.01) .10 1 (1-1) .99
TDF exposure 5.42 (3.38-8.7) <.001 0.77 (0.39-1.55) .37
144 (3244/8303) Males 1.04 (0.85-1.27) .68 1.08 (0.56-2.1) .77
Age, years 1.01 (1-1.02) .17 0.98 (0.92-1.06) .55
WHO stage 3 and 4 1.33 (1.1-1.61) <.001 1.35 (0.52-3.51) .43
CD4 cells/mm3 ≤100 1.06 (0.87-1.3) .56 1.24 (0.59-2.62) .48
VL >10 000 copies/mL 0.92 (0.75-1.12) .41 1.1 (0.42-2.87) .79
HBV positive 1.35 (1.1-1.66) <.001 1.18 (0.88-1.58) .23
Baseline GFR 1 (1-1) .10 1 (0.99-1.01) .47
TDF exposure 4.71 (3.72-5.97) <.001 2.36 (1.28-4.34) .02

Abbreviations: aOR, adjusted odds ratio; ART, antiretroviral therapy; CI, confidence interval; GFR, glomerular filtration rate; HBV, hepatitis B virus; TDF, tenofovir disoproxil fumarate; VL, viral load; WHO, World Health Organization.