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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: Microbiol Spectr. 2019 May;7(3):10.1128/microbiolspec.PSIB-0025-2018. doi: 10.1128/microbiolspec.psib-0025-2018

Figure 4. Domain organization in the canonical SecA of Escherichia coli and SecA2 proteins of S. gordonii and M. tuberculosis.

Figure 4.

Domains were identified in SecA2 proteins by alignment with E. coli SecA using published domain boundaries (92). NBD, nucleotide binding domain; PPXD, preprotein cross-linking domain; HSD, helical scaffold domain; HWD, helical wing domain; IRA, intramolecular regulator of ATPase activity; CTD, C-terminal domain. When compared to the canonical SecA, SecA2 proteins have deletions in the HWD and CTD regions. Amino acid number in the protein sequence is shown below each schematic.