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. Author manuscript; available in PMC: 2019 Jul 22.
Published in final edited form as: J Leukoc Biol. 2019 Jan 28;105(6):1099–1110. doi: 10.1002/JLB.4HI0918-364RR

Figure 3. Topical application of anti-psl MAb Cam003 is not protective.

Figure 3

(A) Percent OPK of P. aeruginosa 6294 grown in a planktonic and microaggregate form. The anti-Psl mAb Cam003 shows significant opsonophagocytic killing against 6294, which is decreased when bacteria are allowed to form microaggregates in vitro. Student’s t-test. (B) Topical application of 400 μg of Cam 003 onto infected eyes does not improve bacterial clearance. The mAb-treated eyes show a twofold increase in bacterial presence. Student’s t-test. p=0.01. Data are representative of three independent experiments. (C) No significant differences in tissue IL-1β, MIP-2, and NE levels among Cam 003-treated and control Ab-treated mice. Student’s t-test. Each symbol represents individual animals.