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Proposed mechanisms mediating cisplatin sensitivity and resistance in TGCTs. Cisplatin resistance mechanisms are classified as pre-target, on-target, post-target and epigenetic mechanisms. ABC: atp-binding cassette transporters; GST: glutathione s-transferase; NER: nucleotide excision repair; MMR: mismatch repair; BER: base excision repair; RA: retinoic acid; RTK: receptor tyrosine kinase; TGCTs: testicular germ cell tumors
