Table 4:
Geometric mean and adequacy of micronutrient intake during 12 months of follow-up in children assigned to LNS or control (intent to treat)
| Baseline | 3 months | 6 months | 9 months | 12 months | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Macronutrient | Control (n=138) | LNS (n=160) | Control (n=128) | LNS (n=149) | Control (n=127) | LNS (n=150) | Control (n=122) | LNS (n=128) | Control (n=111) | LNS (n=129) |
| Total Vitamin A (IU) | ||||||||||
| Geometric mean | 569.4 (438.6, 739.1) | 427.1 (324.2, 562.8) | 740.5 (602.5, 910.1) | 1326.9 (1101.9, 1597.8) | 942.4 (773.2, 1148.5) | 1729.5 (1470.8, 2033.8) | 1205.4 (1032.6, 1407.1) | 2007.5 (1759.5, 2290.5) | 2052.3 (1684.1, 2500.9) | 2626.8 (2335.0, 2955.1) |
| Difference in mean log vit A1 | - | −0.28* | - | 0.84*** | - | 0.86*** | - | 0.71*** | - | 0.52** |
| Total Vitamin B12 (µg) | ||||||||||
| Geometric mean | 0.2 (0.2, 0.3) | 0.1 (0.1, 0.2) | 0.4 (0.3, 0.5) | 0.8 (0.6, 1.0) | 0.8 (0.6, 0.9) | 1.3 (1.1, 1.6) | 0.9 (0.7, 1.1) | 1.3 (1.1, 1.5) | 1.3 (1.1, 1.5) | 1.7 (1.5, 1.9) |
| Difference in mean log B121 | - | −0.30 | - | 1.01*** | - | 0.80*** | - | 0.57** | - | 0.45* |
| Folate (µg) | ||||||||||
| Geometric mean | 63.4 (50.8, 79.1) | 45.9 (37.0, 57.0) | 99.7 (85.6, 116.2) | 159.2 (134.2, 188.9) | 145.2 (130.1, 162.2) | 238.9 (211.2, 270.3) | 151.1 (136.6, 167.1) | 237.1 (213.4, 267.4) | 186.1 (167.9, 206.4) | 283.9 (256.9, 313.7) |
| Difference in mean log folate1 | - | −0.30* | - | 0.78*** | - | 0.79*** | - | 0.69*** | - | 0.72*** |
| Iron (mg) | ||||||||||
| Geometric mean | 2.0 (1.6, 2.6) | 1.5 (1.2, 1.9) | 3.3 (2.8, 4.0) | 7.0 (5.7, 8.6) | 5.0 (4.4, 5.7) | 10.6 (9.2, 12.2) | 5.2 (4.5, 5.9) | 10.0 (8.7, 11.4) | 6.3 (5.6, 7.2) | 11.3 (10.0, 12.8) |
| Difference in mean log iron1 | - | −0.27 | - | 1.02*** | - | 1.00*** | - | 0.86*** | - | 0.83*** |
| Zinc (mg) | ||||||||||
| Geometric mean | 1.2 (1.0, 1.5) | 0.9 (0.8, 1.1) | 1.9 (1.6, 2.2) | 5.2 (4.3, 6.3) | 3.0 (2.7, 3.4) | 8.1 (6.9, 9.5) | 3.2 (2.8, 3.6) | 7.8 (6.7, 9.1) | 4.0 (3.6, 4.5) | 8.6 (7.4, 9.9) |
| Difference in mean log zinc1 | - | −0.24 | - | 1.23*** | - | 1.20*** | - | 1.05*** | - | 0.96*** |
Values are geometric means (95% confidence intervals) and proportions.
1
Differences in mean values and P-values for the differences were obtained from longitudinal mixed models accounting for clustering at the village and individual levels and controlling for age, breastfeeding status, and season. P-values at baseline indicate the difference between study arms at that time point. P-values for later visits compare the difference between study arms in change from baseline to that time point.
*
P<0.05,
**
P<0.01,
***
P<0.001