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Effect of Hsp104 expression on yeast prion propagation. Pink diamonds represent amyloid fibers, and red triangles represent soluble prionogenic protein. Deletion of the HSP104 gene results in the loss of all amyloid yeast prions, as does chemical inhibition of Hsp104 ATPase activity by guanidine hydrochloride. Overexpression of Hsp104 destabilizes [URE3] and results in the efficient curing of the prion [PSI+], but not other prions (Matveenko et al. 2018)
