Table 3.

Immunohistochemical characteristics of fresolimumab-induced neoplasms

Patient	Location	Ki-67	P53	HL	HH	Diagnosis	Comments
007	Skin, ear	+	-	-	-	KA
	Skin, ear	++	-	-	-	KA
	Skin, submandibular	++	-	-	-	KA
	Skin, neck	0	0	-	++	KA
	Skin, forearm	0	0	+	-	KA
	Skin, shoulder	+	-	-	-	KA	Probably early lesion
	Skin, lateral eye	++	-	-	-	pilomatricoma
018	Skin, forearm	++	++	-	-	Hypertrophic Actinic keratosis
	Skin, preauricular	0	0	-	-	KA
	Skin, distal arm	+	+	-	-	KA
	Skin, clavicle	++	-	-	-	KA (atypical)
	Skin, clavicle	++	+	-	-	KA
	Skin, post-auricular	++	+	-	-	SCC microinvasive	Some features of KA. Central review different from local site diagnosis of KA
	Skin, thigh	+	-	-	+	KA
	Skin, shoulder	0	0	-	-	KA
	Skin, subscapular	+	-	-	+	KA
	Skin, parascapular	+	-	-	-	KA
009	Skin, mid-back	+	++	-	-	KA (atypical)	Central review different from local site diagnosis of SCC

Ki67, MIB1 proliferative marker; +, low proliferation mostly at the periphery of the lesion; ++, high proliferation seen in growing phase of SCC or keratoacanthomas; P53, oncogene expressed only on mutant keratinocytes; HL, low-risk HPV mRNA by in situ hybridization; +, trace of uncertain significance; ++, positive focally; HH, high-risk HPV mRNA by in situ hybridization (HPV 16/18/33 are associated with certain SCC especially in mucosal surfaces), +, trace; ++, positive