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. Author manuscript; available in PMC: 2019 Dec 20.
Published in final edited form as: Nanoscale Adv. 2019 Jul 30;1(9):3424–3442. doi: 10.1039/c9na00334g

Figure 6. Time-dependent mRNA profiles of QD-induced proinflammatory and metallothionein markers in OWH slices.

Figure 6.

Fold-changes in mRNA expression were measured at 1 h, 6 h, and 24 h of QD-MPA (orange), QD-PEG-OH (red), and QD-PEG-OMe (blue) exposure at 0.1 μM concentration in OWH slices. The fold-changes were measured for (A) metallothionein isoforms Mt1, Mt2A, and Mt3 and (B) proinflammatory cytokines IL-6, TNF-α, and IL-1β, and compared to NT slices (black). For 1 h, 6 h, and 24 h time points, n = 3 groups and n = 3–6 slices per group were evaluated for each experimental sample (except for the QD-PEG-OMe 6h proinflammatory sample, where n = 2 groups with n = 6 slices in total were evaluated). All data are reported as median values with 95% confidence intervals.