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PDAC-associated 5hmC Loci are enriched in gene bodies. (A) The heatmap shows the detected 1,118 differentially modified 5hmC loci (Bonferroni-corrected p-value < 0.05) between PDAC tumor and adjacent tissues; (B) The detected PDAC-associated 5hmC loci are enriched with gene bodies and histone modification marks for enhancers and active gene expression (e.g. H3K4me1, H3K27ac) derived from the pancreas from the Roadmap Epigenomics Project.
