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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Epigenomes. 2019 Aug 10;3(3):16. doi: 10.3390/epigenomes3030016

Figure 3.

Figure 3.

Functional relevance, prognostic value and cancer specificity of PDAC-associated 5hmC Loci. (A) The host genes containing PDAC-associated 5hmC loci are enriched with certain KEGG pathways and GO biological processes relevant to cancer pathobiology (Fisher Exact Test p- value < 0.01, gene count > 5); (B) Evaluation of prognostic value of PDAC-associated 5hmC loci using a permutation test (N = 100,000), based on the PDAC dataset from the HPA database. The real data point, representing the number of PDAC-associated 5hmC loci with survival relevance in the HPA, is shown as a red vertical line; (C) Evaluation of pancreatic cancer-specific gene expression of PDAC-associated 5hmC loci using a permutation test (N = 100,000), based on the PDAC dataset from the HPA database. The real data point, representing the number of PDAC-associated 5hmC loci with elevated mRNA expression in PDAC in the HPA, is shown as a red vertical line.