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. Author manuscript; available in PMC: 2019 Sep 4.
Published in final edited form as: ACS Pharmacol Transl Sci. 2019 Jul 17;2(4):247–263. doi: 10.1021/acsptsci.9b00020

Figure 8. Combination treatment partially rescues myotonia in the HSALR DM1 mouse model.

Figure 8.

(A) Myotonia in the quadriceps muscle of HSALR mice treated with erythromycin (EM, green), pafuramidine (PaF, blue) or the combination (EM+PaF, magenta) determined via electromyography. (B) Immunofluorescence in quadriceps muscle of untreated (HSALR), erythromycin (EM), pafuramidine (PaF) and combination-treated (HSALR + EM + PaF) HSALR mice against chloride channel, Clcn1 (green). DAPI shown in blue.