Scalability of r-index, Bowtie, and CHIC (RLZ compressed, FMI kernel) indexes against chr19 haplotype collection size and total sequence length (megabases) with respect to index construction time (seconds) (a), index construction peak memory (megabytes) (b), index disk space (megabytes) (c), and locate time (seconds) of 100,000 100bp queries (d). Four different CHIC indexes were used, using different combinations of prefix size and maximum query length, each labeled as CHIC_(prefix size)p_(max query length).