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. Author manuscript; available in PMC: 2020 Feb 7.
Published in final edited form as: ACS Pharmacol Transl Sci. 2019 Mar 18;2(2):92–100. doi: 10.1021/acsptsci.8b00048

Figure 6.

Figure 6.

CCG-257081 prevents bleomycin-induced fibrosis. Mice treated daily with 50 mg/kg CCG-257081 had significantly reduced skin thickness as compared to vehicle control. (A) Masson’s trichrome stained skin sections from vehicle-treated mice (left panel) bleomycin-treated mice (middle panel) and bleomycin+CCG-257081-treated mice (right panel). N = 7. (B) Quantification of (A) by measuring the maximal distance between the epidermal–dermal junction and the dermal-subcutaneous fat junction. Mean values ± SEM are displayed as bar graphs as well as individual values (circles) are displayed. **, p < 0.01 using an unpaired t test. (C) Quantification of collagen using hydroxyproline measurements. Mean values ± SEM (bar graphs) as well as individual mean values (circles) are displayed. *, p < 0.05 using an unpaired t test.