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The α2- α4 helix region indicates the breakage/cleavage domain of human TopoII (blue) and the corresponding domain in E. coli (green) and S. cerevisiae (pink). The residue Ser763α human TopoII (corresponding to Ser83 in E. coli and Ser740 in S. cerevisiae) is represented in licorice. Quinoline resistance in EcGyrA has been attributed to Ser83 mutations. S740W in ScTopoII has been shown to be hypersensitive to etoposide and resistant to CP-115,953.93
