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. Author manuscript; available in PMC: 2020 Feb 13.

Published in final edited form as: J Neurochem. 2019 Nov 4;152(2):235–251. doi: 10.1111/jnc.14898

Table 2.

Data analysis of all assay results of the caudate and putamen of the ten AD cases chosen for BACE1 mRNA analysis and age-matched controls

Assays		Caudate		Putamen

		Mean ± SME	p value	Mean ± SME	p value
8-oxo-dG (pg/μg total DNA)	Control	20.67 ± 2.581		16.59 ± 1.928
8-oxo-dG (pg/μg total DNA)	AD	26.49 ± 7.545	˃ 0.05	14.17 ± 0.823	˃ 0.05

8-oxo-G (pg/μg total DNA)	Control	33.08 ± 4.313		48.41 ± 6.115
8-oxo-G (pg/μg total DNA)	AD	22.07 ± 1.838*	0.0376	37.46 ± 4.851	˃ 0.05

Dopamine (ng/g wet wt)	Control	19.29 ± 6.986		17.21 ± 5.083
Dopamine (ng/g wet wt)	AD	29.66 ± 9.108	˃ 0.05	25.89 ± 4.060	˃ 0.05

VMAT2 Density (fmol/mg)	Control	133.5 ± 10.28		123.4 ± 10.62
VMAT2 Density (fmol/mg)	AD	176.6 ± 17.08	0.051	152.5 ± 18.34	˃ 0.05

D1 Receptor Density (fmol/mg)	Control	25.28 ± 3.410		24.63 ± 3.318
D1 Receptor Density (fmol/mg)	AD	43.98 ± 1.292****	< 0.0001	40.38 ± 2.904**	0.0030

BACE1 mRNA Levels	Control	2.804 ± 0.1252		2.664 ± 0.092
BACE1 mRNA Levels	AD	2.948 ± 0.1615	˃ 0.05	3.025 ± 0.101*	0.0197