Table 7:

Performance of predicting Hamilton Depression Rating Scale (HAMD) total score and its factor scores in Major Depressive Disorder. Mean±SD were based on 10 sets of average performance measures from repeated 5-fold cross validation using 39 features. PLR: penalized logistic regression model with elastic net penalty, SVM: support vector machine, RF: random forest; RMSE: root mean squared error

Variable	RMSE			R2
	PLR	SVM	RF	PLR	SVM	RF
HAMD Score	4.6019 ± 0.0851	4.3408 ± 0.0628	4.5138 ± 0.0793	0.0516 ± 0.0219	0.1301 ± 0.0274	0.0632 ± 0.0237
Factor 1: Psychic Depression	2.0498 ± 0.0381	1.9742 ± 0.0140	2.0226 ± 0.0393	0.0261 ± 0.0096	0.0334 ± 0.0100	0.0302 ± 0.0173
Factor 2: Motivation	1.1802 ± 0.0245	1.1904 ± 0.0138	1.2130 ± 0.0189	0.0662 ± 0.0265	0.0349 ± 0.0198	0.0224 ± 0.0150
Factor 4: Anxiety	1.2812 ± 0.0202	1.2328 ± 0.0095	1.2933 ± 0.0199	0.0286 ± 0.0262	0.0374 ± 0.0233	0.0358 ± 0.0170
Factor 5: Sleep	1.4344 ± 0.0204	1.3926 ± 0.0141	1.3649 ± 0.0157	0.0299 ± 0.0098	0.0502 ± 0.0115	0.0856 ± 0.0227