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. Author manuscript; available in PMC: 2020 Feb 11.
Published in final edited form as: FASEB J. 2019 Nov 28;34(1):912–929. doi: 10.1096/fj.201902359R

Fig. 4.

Fig. 4.

Selected phospholipid molecular species of WT, Adipor1−/−, and Mfrprd6 mouse retinas. 22:6- or 20:4-containing PC, PE and PS (except for PE(22:1/22:0) and PS(22:1/22:0)) are shown in the box plots. 20:4-containing PC, PE and PS are abundant in the mutant retinas. In both mutants, there is a great reduction of all the phospholipids containing two 22:6 molecules (PC, PE or PS(22:6/22:6)) and PCs composed of 22:6 and VLC-PUFAs (PC(22:6/32:6), PC(22:6/34:6), and PC(22:6/36:6)). On the other hand, single 22:6-containing PEs, such as PE(18:0/22:6), do not show differences among the groups, however, PE(22:6/24:6) shows greatly reduced amounts in both mutant retinas compared to WT. Interestingly, non-22:6 or −20:4 containing PE(20:0/22:1), also shows great reduction in the mutants. For PS species, single 22:6-containing molecular species show higher abundances in the mutants while PS(22:6/24:6) and PS(22:0/22:1) show significant reduction in mutants.