Table 2.
Patient-Reported Outcomes by Type of Testing Offered Using Imputed Data
| Scale and Time Point | Mean Score (95% CI) | P | Difference in Change (95% CI) |
|
|---|---|---|---|---|
| Targeted Testing Offered (n = 178) |
Multigene Panel Testing Offered (n = 314) |
|||
| Genetic knowledge (score range, 6–28) | ||||
| After pretest counseling | 23.28 (22.89 to 23.67) | 22.45 (22.89 to 23.67) | NSS | −0.12 (−0.71 to 0.46) |
| After disclosure | 23.79 (23.36 to 24.23) | 22.65 (23.36 to 24.23) | NSS | −0.46 (−1.14 to 0.21) |
| Change score | 0.51 (0.09 to 0.92) | 0.21 (0.09 to 0.92) | NSS | −0.34 (−1.00 to 0.32) |
| General anxiety (score range, 0–21) | ||||
| After pretest counseling | 7.07 (6.50 to 7.65) | 6.58 (6.50 to 7.65) | .04 | −0.94 (−1.84 to −0.04) |
| After disclosure | 6.97 (6.36 to 7.58) | 6.31 (6.36 to 7.58) | NSS | −0.73 (−1.71 to 0.24) |
| Change score | −0.11 (−0.60 to 0.39) | −0.27 (−0.60 to 0.39) | NSS | 0.21 (−0.54 to 0.95) |
| General depression (score range, 0–21) | ||||
| After pretest counseling | 3.01 (2.55 to 3.47) | 2.79 (2.55 to 3.47) | .04 | −0.77 (−1.49 to −0.05) |
| After disclosure | 3.21 (2.71 to 3.71) | 3.10 (2.71 to 3.71) | NSS | −0.24 (−1.00 to 0.52) |
| Change score | 0.20 (−0.24 to 0.63) | 0.30 (−0.24 to 0.63) | NSS | 0.53 (−0.08 to 1.14) |
| State anxiety (score range, 20–80) | ||||
| After pretest counseling | 36.48 (34.62 to 38.34) | 34.10 (34.62 to 38.34) | .03 | −3.37 (−6.42 to −0.33) |
| After disclosure | 37.50 (35.52 to 39.48) | 34.35 (35.52 to 39.48) | .05 | −3.07 (−6.13 to −0.01) |
| Change score | 1.02 (−0.69 to 2.73) | 0.25 (−0.69 to 2.73) | NSS | 0.30 (−2.29 to 2.89) |
| Cancer-specific distress (score range, 0–70) | ||||
| After pretest counseling | 16.63 (14.54 to 18.71) | 17.77 (14.54 to 18.71) | NSS | −1.06 (−4.30 to 2.19) |
| After disclosure | 19.98 (17.59 to 22.38) | 18.05 (17.59 to 22.38) | .05 | −3.76 (−7.42 to −0.09) |
| Change score | 3.36 (1.59 to 5.13) | 0.28 (1.59 to 5.13) | NSS | −2.70 (−5.52 to 0.12) |
| Uncertainty (score range, 0–15) | ||||
| After pretest counseling | 6.35 (5.74 to 6.96) | 5.58 (5.74 to 6.96) | .05 | −1.01 (−2.01 to −0.01) |
| After disclosure | 6.40 (5.65 to 7.15) | 6.53 (5.65 to 7.15) | NSS | 0.24 (−0.98 to 1.45) |
| Change score | 0.05 (−0.69 to 0.79) | 0.68 (−0.69 to 0.79) | .04 | 1.25 (0.06 to 2.44) |
| Satisfaction (score range, 9–45) | ||||
| After pretest counseling | 38.57 (37.97 to 39.18) | 39.15 (37.97 to 39.18) | NSS | 0.72 (−0.26 to 1.71) |
| After disclosure | 38.48 (37.65 to 39.31) | 39.53 (37.65 to 39.31) | NSS | −0.23 (−1.58 to 1.13) |
| Change score | −0.09 (−0.92 to 0.74) | 0.38 (−0.92 to 0.74) | NSS | −0.95 (−2.31 to 0.41) |
NOTE. Calculations were adjusted for age, sex, race (white v nonwhite), education (college graduate v less than a college degree), Jewish ethnicity (no or missing v yes), number of first- and second-degree relatives with cancer, known cancer mutation, treatment decision, random assignment or self-selecting for in-person disclosure arm, and study site.
Abbreviation: NSS, not statistically significant (P > .05).