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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Leukemia. 2019 Jul 11;33(11):2746–2751. doi: 10.1038/s41375-019-0514-9

Fig. 1.

Fig. 1

Novel ALL GWAS association locus at ERG on chromosome 21. a Manhattan plot displaying genome-wide −log10(P) values from a meta-analysis of three Latino ALL GWAS (n = 2,299 cases and 9,087 controls), in the California Cancer Records Linkage Project (CCRLP), the California Childhood Leukemia Study (CCLS), and a Guatemalan ALL study. Grey horizontal line represents the genome-wide significance threshold of P = 5.0 × 10−8. Genome-wide significant signals were observed at 7 known loci at, in chromosomal order, IKZF1, CDKN2A, GATA3, BMI1, PIP4K2A, ARID5B, and CEBPE, as well as a novel locus at ERG on chromosome 21. b Locus Zoom plot of a ~500Kb region at chromosome 21q22.2 encompassing ERG. The −log10(P) values were calculated from meta-analysis of the three Latino case-control studies. The ALL association peak is flanked by two recombination hotspot peaks, represented by vertical blue lines