Table 3.

Test characteristics and performance of TMB cut-off values in the joint ICI cohort (n = 499). Right-most columns describe number of patients with DCB who would not have been treated at that threshold (false negative), and the number of patients who would have been treated with NDB (false positive).

Abbreviations: DCB, durable clinical benefit; NDB, no durable benefit; OR, odds ratio; Sens, sensitivity; Spec, specificity; TMB, tumor mutational burden.

Z-score cut-off	DFCI TMB	MSKCC TMB	% Sens.	% Spec.	% DCB	OR (p-value)	# ≥ cut- off (%)	# with DCB not treated (%)	# treated w/ NDB (%)
−0.46	7.34	3.77	86.2	24.2	33	1.99 (0.008)	394 (79)	21 (4)	263 (53)
0.28	11.9	7.18	61.8	57.3	39	2.10 (< 0.001)	245 (49)	58 (12)	151 (30)
1.08	20.6	15.1	26.3	88.2	54	2.99 (< 0.01)	80 (16)	111 (22)	39 (8)
3.10	61.4	68.2	0.7	99.7	67	4.60 (0.22)	3 (1)	150 (30)	1 (0.2)