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. Author manuscript; available in PMC: 2020 Dec 3.
Published in final edited form as: Neuropathol Appl Neurobiol. 2020 Jan 14;46(6):546–563. doi: 10.1111/nan.12596

Fig. 2. Higher expression of miR155 and HO-1 in TSC and FCD IIb.

Fig. 2

(A) Expression of miR155 was predominately found in neurons of the grey matter (GM) with low expression in glia of the white matter (WM) (arrowheads). (B, C) In contrast, miR155 expression was predominantly found in GFAP-positive cells with glial morphology and giant/balloon cells in FCD IIb and TSC as compared to control, whereas expression in dysmorphic neurons did not differ from control. (D) Expression of total miR155 in TSC tissue was higher than in control. (E, F) Moreover, HO-1 RNA expression was higher in surgically resected tuber tissue from TSC patients compared to autoptic control, while HO-1 protein expression was high only in a subset of patients. (G, H) miR155 expression was not different between autopsy control tissue and FCD IIb, while HO-1 RNA was higher. Mann-Whitney U-test. Data are expressed relative to expression observed in controls. Error bars represent range; ** p<0.01. n = 8 (Autopsy control, FCD IIb), n = 10 (TSC). Scale bar 100 µm in A (representative for A–C), arrows = dysmorphic neurons, arrowheads = glia, asterisk = balloon/giant cells