Table 2.
Greater activation in OCD patients than controls during early eyeblink suppression.
| Label | Harvard-Oxford Parcel | BA | k | x | y | z |
|---|---|---|---|---|---|---|
| Frontal/Insular | ||||||
| Inferior frontal gyrus/orbital gyrus | Frontal Orbital Cortex (L) | 47 | 20 | −42 | 18 | −8 |
| Insula/inferior frontal gyrus | Insular Cortex (L) | 13, 47 | 126 | −36 | 6 | −12 |
| Insula/claustrum | Insular Cortex (L) | 42 | −32 | 12 | 0 | |
| Mid cingulate/anterior cingulate | Cingulate Gyrus, Anterior (L) | 24, 32 | 80 | −6 | 10 | 30 |
| Parietal | ||||||
| Paracentral lobule/precuneus/postcentral gyrus | Postcentral Gyrus (R) | 4, 5 | 28 | 14 | −42 | 56 |
| Inferior parietal lobule/supramarginal gyrus/ angular gyrus |
Angular Gyrus (L) | 40 | 246 | −50 | −56 | 26 |
| Inferior parietal lobule/supramarginal gyrus/ angular gyrus |
Angular Gyrus (R) | 40 | 315 | 54 | −44 | 24 |
| Inferior parietal lobule/superior parietal lobule | Superior Parietal Lobule (L) | 7, 40 | 178 | −32 | −54 | 38 |
| Inferior parietal lobule/superior parietal lobule | Superior Parietal Lobule (R) | 7, 40 | 218 | 32 | −46 | 38 |
| Inferior parietal lobule/supramarginal gyrus | Supramarginal Gyrus, Anterior (L) | 40 | 128 | −60 | −38 | 36 |
| Inferior parietal lobule/supramarginal gyrus | Supramarginal Gyrus, Posterior (L) | 40 | 323 | −58 | −52 | 30 |
| Inferior parietal lobule/supramarginal gyrus/ postcentral gyrus |
Supramarginal Gyrus, Posterior (R) | 40 | 464 | 52 | −44 | 22 |
| Superior parietal lobule/middle occipital gyrus/ precuneus/inferior parietal lobule/angular gyrus |
Lateral Occipital Cortex, Superior (L) | 7, 19, 39, 40 | 620 | −22 | −82 | 20 |
| Angular gyrus/superior parietal lobule/inferior parietal lobule/precuneus/middle occipital gyrus |
Lateral Occipital Cortex, Superior (R) | 7, 39, 40 | 337 | 42 | −62 | 30 |
| Mid cingulate/posterior cingulate/precuneus | Cingulate Gyrus, Posterior (B) | 23, 24, 31 | 555 | −2 | −38 | 24 |
| Posterior cingulate/precuneus/lingual gyrus | Cingulate Gyrus, Posterior (B) | 29 | 28 | 22 | −48 | 2 |
| Precuneus/cuneus/mid cingulate/posterior cingulate/superior parietal lobule/paracentral lobule | Precuneous Cortex (B) | 5, 7, 20, 31 | 1702 | 10 | −54 | 4 |
| Calcarine/posterior cingulate | Precuneous Cortex (L) | 30 | 20 | −20 | −62 | 4 |
| Occipital | ||||||
| Calcarine/cuneus/posterior cingulate/lingual gyrus | Intracalcarine Cortex (L) | 17, 18, 23, 30 | 173 | −16 | −68 | 2 |
| Calcarine/cuneus/posterior cingulate/lingual gyrus | Intracalcarine Cortex (R) | 30 | 72 | 22 | −64 | 2 |
| Cuneus/calcarine/lingual gyrus | Intracalcarine Cortex (R) | 30 | 53 | 6 | −84 | 0 |
| Calcarine/posterior cingulate/cuneus | Supracalcarine Cortex (R) | 31 | 41 | 22 | −64 | 12 |
| Cuneus | Supracalcarine Cortex (R) | 17, 18 | 21 | 2 | −86 | 4 |
| Lingual gyrus/cuneus/parahippocampal gyrus/precuneus | Lingual Gyrus (L) | 18, 19, 30 | 120 | −16 | −48 | −4 |
| Lingual gyrus/cerebellum | Lingual Gyrus (L) | 67 | −18 | −66 | −14 | |
| Lingual gyrus/calcarine/cuneus | Lingual Gyrus (R) | 18, 30 | 119 | 10 | −88 | −12 |
| Lingual gyrus/calcarine/parahippocampal gyrus | Lingual Gyrus (R) | 18, 19, 30 | 56 | 20 | −76 | −4 |
| Cuneus/precuneus/superior occipital gyrus | Cuneal Cortex (L) | 7, 18, 19, 31 | 198 | −14 | −74 | 18 |
| Cuneus/precuneus | Cuneal Cortex (R) | 7, 18, 19, 31 | 389 | 2 | −88 | 14 |
| Middle occipital gyrus/inferior occipital gyrus/inferior temporal gyrus | Lateral Occipital Cortex, Inferior (L) | 19, 37, 39 | 316 | −42 | −70 | −12 |
| Middle occipital gyrus | Lateral Occipital Cortex, Inferior (R) | 19 | 31 | 36 | −82 | 6 |
| Middle occipital gyrus/middle temporal gyrus | Lateral Occipital Cortex, Superior (L) | 19 | 83 | −34 | −88 | 6 |
| Middle occipital gyrus/ middle temporal gyrus | Lateral Occipital Cortex, Superior (R) | 19 | 85 | 38 | −82 | 10 |
| Middle occipital gyrus | Lateral Occipital Cortex, Superior (R) | 19 | 53 | 28 | −72 | 22 |
| Cuneus/middle occipital gyrus/superior occipital gyrus/calcarine | Occipital Pole (L) | 17, 18, 19 | 265 | −4 | −92 | −2 |
| Cuneus/calcarine | Occipital Pole (R) | 18, 19 | 29 | 4 | −90 | 4 |
| Subcortical | ||||||
| Caudate head | Caudate (L) | 44 | −14 | 16 | −4 | |
| Putamen (lentiform nucleus) | Putamen (L) | 123 | −26 | 4 | −10 | |
| Putamen (lentiform nucleus) | Putamen (L) | 29 | −32 | −16 | −8 | |
| Hippocampus/thalamus | Thalamus (L) | 27 | 31 | −20 | −34 | −4 |
| Hippocampus/parahippocampal gyrus | Hippocampus (L) | 27, 30 | 73 | −24 | −30 | −12 |
| Cerebellum (culmen/declive) | Cerebellum Crus 1 (R) | 181 | 42 | −52 | −36 | |
| Cerebellum (culmen/declive) | Cerebellum 4_5 (L) | 49 | −10 | −56 | −22 | |
| Cerebellum (culmen/declive) | Cerebellum 6 (L) | 217 | −14 | −64 | −28 | |
| Cerebellum (culmen/declive) | Cerebellum 6 (R) | 345 | 30 | −56 | −34 | |
| Cerebellum (declive) | Vermis 6 (B) | 51 | −4 | −62 | −24 | |
| Cerebellum (declive) | Vermis 7 (B) | 27 | 6 | −66 | −26 |
Labels are derived from the Automated Anatomical Labeling and Talairach Daemon databases as provided through xjview (v. 9.6, http://www.alivelearn.net/xjview). Harvard-Oxford Atlas parcels are provided through the ‘conn’ tool (Whitfield-Gabrieli & Nieto-Castanon, 2012). Within a given cluster, labels are listed in descending order based on the proportion of voxels within the cluster assigned to that label. Some clusters span across two different lobes; for these clusters, lobe assignment is based on the lobe with the greatest proportion of voxels in that cluster.
BA=Brodmann’s areas; k=cluster extent; R=right, L=left, B=bilateral; coordinates are in MNI space. Only clusters with 20 or more contiguous voxels are listed. Parcels represent subdivisions from clusters corrected for a whole-brain family-wise error rate of p<0.05 using permutation testing.