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SINV replication in neurons is affected by mutations in the nsP3 macro domain. Undifferentiated CSM14.1 (A), 3 week-differentiated CSM14.1 (B) and BHK21 (C) cells were infected with SINV WT, SM10, SM24, or DM (MOI = 10). Virus released into cell culture media was assessed by plaque assay. Average data of two independent experiments are presented. Error bars indicate standard error of the mean. * P < 0.05; ** P < 0.01; *** P < 0.001;Student’s t-test comparing SINV WT and DM.
