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. Author manuscript; available in PMC: 2010 Jan 7.
Published in final edited form as: J Neurosci. 2009 Jan 7;29(1):280–287. doi: 10.1523/JNEUROSCI.4267-08.2009

Figure 5.

Figure 5

Effect of combined NPY and DBH siRNA injection on lipoprivic feeding and target gene expression. A shows the effect of DBH siRNA (0.02 nmol) + NPY siRNA (0.02 nmol) (Mixed siRNAs) or control ntRNA injected bilaterally into A1/C1 on 4h saline- or MA (68 mg/kg)-induced feeding. MA-induced feeding did not differ between the combined siRNA- and ntRNA-injected rats. B shows numbers of DBH- and TH-immunoreactive cells in A1/C1, quantified from rats used in lipoprivic feeding tests. DBH siRNA/NPY siRNA mixture injected into A1/C1 significantly inhibited DBH expression, but not TH expression in A1/C1 region. **p < 0.001 (vs control).