The amount of cocaine ingested by LgA and ShA rats on the test days was calculated based on data in Figure 2. Data on table are represented as mean ± S.E.M. Analysis of the cocaine intake paired-data presented in the table (LgA versus ShA, t-test) shows differences in the amount of cocaine between vehicle-injected LgA and ShA animals and no differences in the amount of cocaine ingested between the two groups on the other test days. This data support the hypothesis that SR141716A acted independently of the amount of cocaine currently in the rat’s system during testing. SR: SR141716A; n.s.: non significant.