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. Author manuscript; available in PMC: 2009 Oct 27.
Published in final edited form as: J Diabetes Sci Technol. 2009 Jan 1;3(1):125–140. doi: 10.1177/193229680900300114
Blood Glucose (mg/dl) Action
Less than 50 Stop Insulin
  • If not alert or if NPO, give 15 ml of D50W IV and if <40 give, 25 ml of D50W IV

  • If alert and taking PO, give 8 oz of juice PO or 6 glucose tablets PO

  • Recheck BG every 30 min until greater than 80 mg/dl

  • If next BG is < 50 mg/dl, double amount of previous treatment, and if next BG is 50–65 mg/dl, repeat treatment

  • When BG is greater than 90 mg/dl, restart insulin rate at 50% of previous rate and recheck BG in 30 min

50 to 64 Stop Insulin
  • If previous BG greater than 100 mg/dl or if symptomatic from hypoglycemia.

  • If NPO, give 15 ml of D50W IV or if taking PO, give 4–6 oz of juice or 3 glucose tablets PO

  • Recheck BG every 30 min until greater than 80 mg/dl

  • If next BG remains 50–64 mg/dl, repeat previous treatment

  • When BG greater than 90 mg/dl, restart insulin rate at 50% of previous rate and recheck BG in 30 min

65 to 79
  • If greater than last test, decrease rate by 0.2 IU/h

  • If lower than last BG by more than 30 mg/dl, stop drip and recheck BG in 30 min (see bold order)

  • If lower than last BG by 15–30 mg/dl, decrease rate by 50% and recheck BG in 30 min

  • If lower than last BG by 7–14 mg/dl, decrease rate by 0.5 IU/h

  • If equal to last BG or lower than last BG by less than 7 mg/dl, decrease rate by 0.3 IU/h

    If infusion turned off, recheck BG in 30 min. When BG greater than 90 mg/dl, restart at 50% of previous rate and recheck BG in 30 min.

  • Recheck BG every 30 min until greater than 80 mg/dl

80 to 120 Target range may titrate drip in ICU to maintain this range.
  • If higher than last BG by more than 10 mg/dl, increase rate by 0.5 IU/h

  • If lower than last BG by more than 40 mg/dl, stop drip and recheck BG in 30 min (see bold order)

  • If lower than last BG by 21–40 mg/dl, decrease rate by 50% and recheck BG in 30 min

  • If lower than last BG by 10–20 mg/dl, decrease rate by 0.5 IU/h

    If infusion turned off, recheck BG 30 min. If/when BG greater than 120 mg/dl, restart at 50% of previous rate.

  • If within 10 mg/dl of last BG, same rate unless the following applies:

  • for any BG in this range (even if within 10 mg/dl of last test), the following always applies:

    If BG has consistently decreased each of last 4 measurements, decrease rate by an additional 0.3 IU/hIf BG has consistently increased each of last 4 measurements, increase rate by an additional 0.2 IU/h

121 to 135
  • If higher than last BG by more than 50 mg/dl, increase rate by 2 IU/h

  • If higher than last BG by 20–50 mg/dl, increase rate by 1 IU/h

  • If higher than last BG by 0–20 mg/dl, increase rate by 0.5 IU/h

  • If lower than last BG by 1–20 mg/dl, same rate

  • If lower than last BG by 21–40 mg/dl, decrease rate by 1 IU/h

  • If lower than last BG by 41–60 mg/dl, decrease rate by 50% and recheck BG in 30 min

  • If lower than last BG by more than 60 mg/dl, stop drip and recheck BG in 30 min (see bold order)

    If infusion turned off, recheck BG 30 min. If/when BG greater than 125 mg/dl, restart at 50% of previous rate.

136 to 150
  • If higher than last BG by more than 30 mg/dl, increase rate by 2 IU/h and bolus with 3 IU IV

  • If higher than last BG by 0–30 mg/dl, increase rate by 1 IU/h and bolus with 2 IU IV

  • If lower than last BG by 1–20, increase rate by 1 IU/h and bolus with 2 IU IV

  • If lower than last BG by 21–50 mg/dl, same rate

  • If lower than last BG by 51–80 mg/dl, decrease rate by 50% and recheck BG in 30 min

  • If lower than last BG by more than 80 mg/dl, stop drip and recheck BG in 30 min (see bold order)

    If infusion turned off, recheck BG 30 min. If/when BG greater than 125 mg/dl, restart at 50% of previous rate.

151 to 180
  • If lower than last BG by more than 80 mg/dl, decrease rate by 50%

  • If lower than last BG by 30 –80 mg/dl, continue same rate

  • If lower than last BG by 0–30, increase insulin rate by 1 IU/h and bolus with 2 IU IV

  • If higher than last BG by 1–20 mg/dl, increase insulin rate by 2 IU/h and bolus with 4 IU IV

  • If higher than last BG by more than 20 mg/dl, increase insulin rate by 3 IU/h and bolus 6 IU IV

  • Recheck BG in 30 min and repeat BG every 30 min until less than 150 mg/dl

181 to 240
  • If lower than last BG by more than 100 mg/dl, decrease rate by 50%

  • If lower than last BG by 50–100 mg/dl, continue same rate

  • If lower than last BG by less than 50 mg/dl or higher than last BG, bolus with 6 IU regular insulin IV and increase insulin rate by 2 IU/h

  • If BG remains 181–240 mg/dl and has not decreased after 3 consecutive increases in insulin:

    1. Give double previous IV bolus dose up to a maximum of 24 units and double insulin drip rate up to a maximum of 20 IU/h

    2. If on 20 IU/h and no response after 4 maximum boluses–call MD for further orders

  • Recheck BG in 30 min and repeat BG every 30 min until less than 150 mg/dl

Greater than 240
  • If lower than last BG by more than 150 mg/dl, decrease rate by 50%

  • If lower than last BG by 101–150 mg/dl : Same rate

  • If lower than last BG by 0–100 mg/dl or if higher than last BG: bolus with 10 units regular insulin IV and double insulin rate up to a maximum of 30 IU/h

  • If BG remains greater than 240 mg/dl and has not decreased after 3 consecutive increases in insulin:

    1. Give double previous IV bolus dose up to a maximum of 40 units and double insulin drip rate up to a maximum of 30 IU/h

    2. If on 30 IU/h and no response after 4 maximum boluses–call MD for further orders

  • Recheck BG in 30 min and repeat BG every 30 min until less than 150 mg/dl

If BG is greater than 300 for 4 consecutive readings, call MD for additional IV bolus orders.