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. Author manuscript; available in PMC: 2009 Jul 17.
Published in final edited form as: J Neurosci. 1995 Jul;15(7 Pt 2):5275–5285. doi: 10.1523/JNEUROSCI.15-07-05275.1995

Figure 7.

Figure 7

Anti-α1 antibodies fail to block outgrowth of CGs, but reduce DRG outgrowth on laminin-1. Dissociated E7 DRGs and CGs were plated on laminin-1 and allowed to extend neurites for 4–5 hr (DRGs) or 8–10 hr (CGs) in the presence of no antibodies (0), anti-β1 mAb (W1B10, 50 μg/ml), anti-p75NGFRmAb (mc 192, 50 μg/ml), anti-α1, serum (1:25), or control serum (NRS, 1:25). The degree of outgrowth reduction observed in the presence of the anti-α1 serum is very similar to that reported by Tomaselli et al. (1993) for human DRG cultured in the presence of a monoclonal anti-α1 antibody. Values represent mean ± SD of at least four determinations from at least two separate experiments, each performed in duplicate.