Table 1.
Neurite lengths in the presence of anti-α6Ex and anti-α3Ex1
| Condition | Laminin (% neurite length) | Merosin (% neurite length) |
|---|---|---|
| nRIgG Fab | 100 ± 5 (79) | 100 ± 9 (38) |
| anti-α6Ex Fab | 71 ± 7 (80)** | 106 ± 9 (40) |
| anti-α3Ex1 Fab | 85 ± 15.8 (80)† | 105 ± 8 (40) |
| α3Ex + α6Ex Fabs | 81 ± 6 (79)* | 105 ± 5 (40) |
| anti-β1 mAb | 0 | 0 |
| anti-p75NGFR mAb | 99 ± 10 (80) | 106 ± 7 (40) |
Representative cultures from the experiments in Figure 6 were examined for effects of integrin-specific antibodies on neurite length. Processes longer than 1 cell body diameter were measured as described in Materials and Methods. Values represent mean neurite length ± SD, normalized to mean length under control conditions. (n) indicates the number of processes measured for each condition. Statistical significance was determined using Dunnett’s test for multiple comparisons against a single control.
*
p < 0.05.
**
p < 0.01.
†
p > 0.05 (not significantly different from control).