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. Author manuscript; available in PMC: 2009 Oct 29.
Published in final edited form as: J Neurosci. 2009 Apr 29;29(17):5508–5515. doi: 10.1523/JNEUROSCI.4288-08.2009

Figure 5. Inhibition of TrkB signaling can reverse already established nerve injury-induced mechanical hyperalgesia.

Figure 5

Partial sciatic nerve injury (SNI) in both wt (n=5) and TrkBF616A (n=5) produced a significant drop of the mechanical withdrawal threshold (A), compared to baseline. Injection of 1NM-PP1 (16.6 ng/gm, i.p.) 3 days after the SNI reversed the mechanical allodynia in TrkBF616A, but not in wt mice. The mechanical threshold in wt mice was significantly lower than in TrkBF616A mice after 1NM-PP1 (**p<.01) and lower than that in the uninjured contralateral paw of the TrkBF616A mice (***p<.001). The reversal lasted from 30-60, reappearing within 90 min of the 1NM-PP1 injection, at which point mechanical thresholds in wt and TrkBF616A mice did not differ and both were significantly lower than in the uninjured paw of the TrkBF616A mice, *** p<0.001. In neither group did SNI produce a change of the withdrawal threshold to noxious heat (B), and 1NM-PP1 injection was without effect in test of heat pain sensitivity.