Table I.
Cell growth inhibition 50 (GI50) of P529 in the NCI-60 tumor cell lines panel
| Panel/cell line | GI50 (μM) |
|---|---|
| Leukemia | |
| CCRF-CEM | |
| HL-60(TB) | 2.28 |
| K-562 | 4.1 1 |
| MOLT-4 | 32.7 |
| RPMI-8226 | 21.5 |
| SR | 2.14 |
| Non-small cell lung cancer | |
| A549/ATCC | 13.1 |
| EKVX | 22.3 |
| HOP-62 | 11.2 |
| NCI-H226 | 21.2 |
| NCI-H23 | 15.1 |
| NCI-H322M | 34.3 |
| NCI-H460 | 11.4 |
| NCI-H522 | 8.84 |
| Colon cancer | |
| COLO 205 | 23.7 |
| HCC-2998 | 12.1 |
| HCT-I 16 | 10.8 |
| HCT-15 | 12.9 |
| HT29 | 6.04 |
| KM 12 | 14.2 |
| SW-620 | 14.5 |
| CNS cancer | |
| SF-268 | 6.09 |
| SF-295 | 12.2 |
| SF-539 | 14.7 |
| SNB-19 | 11.2 |
| SNB-75 | 5.18 |
| U25I | 12 |
| Melanoma | |
| LOX IMVI | 22.5 |
| MALME-3M | 17.2 |
| MI4 | 16.4 |
| SK-MEL-2 | 18.6 |
| SK-MEL-26 | 14.5 |
| SK-MEL-5 | 9.12 |
| UACC-257 | 15.4 |
| UACC-62 | 12.1 |
| Ovarian cancer | |
| ICROVI | 14.9 |
| OVCAR-3 | 12.8 |
| OVCAR-4 | 12.8 |
| OVCAR-5 | 24.1 |
| OVCAR-8 | 9.02 |
| SK-OV-3 | 13.6 |
| Renal cancer | |
| 786-0 | 16.2 |
| A496 | 15.9 |
| ACHN | 13.3 |
| CAKI-1 | 11.2 |
| RXF 393 | 5.24 |
| SN 12C | 17 |
| TK-10 | 18.2 |
| UO-31 | 15.5 |
| Prostate cancer | |
| PC-3 | 12.4 |
| DU-145 | 18.6 |
| Breast cancer | |
| MCF7 | 6.01 |
| NCI/ADR-RES | 12.6 |
| MDA-MB-23 I/ATCC | 14.7 |
| HS 578T | 13.3 |
| MDA-MB-435 | 2.64 |
| BT-549 | 17 |