Figure 3. Genetic deletion of PSD-95 leads to an accelerated turnover of 5- HT_2A receptor protein.

(A) and (B) represent fitted curves modeling 5-HT_2A receptor turnover in PSD- 95^wildtype and PSD-95^null mice, respectively, (N=3–4 littermate pairs at each data point). Visual inspection shows that steady state levels for the 5-HT_2A receptor are reached sooner in the absence of PSD-95, suggesting accelerated turnover. The higher k in PSD-95^null cortex indicates a higher rate of receptor turnover in the absence of PSD-95. Rate constant, k, is a non least squares fitted parameter of an equation modeling receptor recovery (see methods for details), +/− SEM. ^*p < .05, ^**p < .01, ^***p < .001; one-tailed unpaired t-test.