Table 1. Genes of interest affected in PSD-95^null mice.

6 transcripts that are downregulated in PSD-95^null mice have been reported to be induced after hallucinogenic drug administration in mice. Most are immediate early genes, which is consistent with a role for PSD-95 in regulating 5-HT_2A signaling.

Gene of Interest	Alternate Names	Dowregulation as % of Wildtype
Arc^b	rg3.1	36.6
egr2^a,^b	krox20; ngf1b; zfp-25; zfp-6	38.6
per1^a	rigui	42.0
Jun-B^a	-	46.7
Nr4a1^a	N-10; gfrp; gfrp1; hbr-1; hmr; np10; tr3; nur77; tis1	50
Homer1a^b,^*	-	35.3

(Gonzalez-Maeso, Yuen et al. 2003)

(Nichols and Sanders-Bush 2002)

the gene previously reported to be upregulated after hallucinogen administration is ania3, a closely related isoform that differs only in the 5′ UTR and a few amino acids at the C-terminus

Table 1. Genes of interest affected in PSD-95null mice.

Table 1. Genes of interest affected in PSD-95^null mice.