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Buprenorphine blocked desensitization induced by etorphine. A. a control experiment showing the desensitization induced by etorphine (1 μM), the reversal of the current induced by naloxone (1 μM) and the current induced by UK14304 (UK, 3 μM). B. an experiment done in a slice that was incubated in buprenorphine (5 nM 1 hr). The current induced by etorphine (1 μM) is significantly smaller and did not desensitize during the 10 min application period.
