Table 1.
Participants' Test Results and Reported Results of Clinical Neuroimaging
| Number | Duration of Illness (Years) | Neuromaging Findings | BNT | WAB Info Content (/10) | WAB Commands (/80) | WAB Repetition (/100) | WAB Fluency (/10) | WAB Aphasia Quotient (/100) | Pyramids and Palm Trees (/52) | Total CIR | FBI Discrepancy Score |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 7 | MRI: Normal | 35 | 9 | 73 | 94 | 6 | 85.2 | ND | 0 | 3 |
| 2 | 4 | MRI: Normal | 60 | 9 | 70 | 78 | 6 | 90.0 | 52 | 0 | 4 |
| EEG: Nonspecific slowing in left hemisphere | |||||||||||
| 3 | 3 | MRS: Focal reduction in NAA concentration left frontal and anterior temporal cortices | 60 | 10 | 68 | 96 | 9 | 95.5 | 52 | 1 | -1 |
| 4 | 3 | MRI: Atrophy and widening of the left perisylvian fissure | 39 | 8 | 62 | 70 | 5 | 93.7 | ND | 1 | -2 |
| 5 | 2 | MRI: Mild age-related atrophy | 44 | 8 | 67 | 66 | 5 | 74.8 | ND | 0 | 1 |
| SPECT: diminished perfusion in the left temporal lobe and posterior parietal lobe | |||||||||||
| 6 | 4 | MRI: Mild to moderate cerebral volume loss, prominent in the medial temporal lobes bilaterally | 52 | 9 | 80 | 70 | 5 | 79.2 | 49 | 0 | -13 |
| EEG: intermittent left hemisphere slowing, especially in temporal region | |||||||||||
| 7 | 3 | MRI: Small vessel ischemic disease, mild hippocampal atrophy | 41 | 10 | 80 | 78 | 9 | 91.6 | 50 | 0 | -6 |
| 8 | 3 | MRI: Increase in size of the left perisylvian cistern | 60 | 10 | 80 | 100 | 9 | 97.4 | 52 | 0 | -2 |
| PET: Mild decrease in parietal and temporal metabolism, more so on the left | |||||||||||
| 9a | 4 | MRI: Mild cortical atrophy | 6 | 9 | 58 | 100 | 8 | 75.4 | 40 | 3 | -19 |
| EEG: Normal | |||||||||||
| 10 | 6 | MRI: Normal other than cerebral atrophy | NA | NA | 78 | NA | NA | NA | 49 | 4 | -5 |
| 11 | 4 | MRI: Mild cerebral atrophy | 58 | 10 | 68 | 10 | 6 | 70.7 | 50 | 0 | 0 |
| EEG: Dysrhythmia and left temporal slowing | |||||||||||
| 12 | 4 | MRI: Some symmetric atrophy | 9 | 5 | 44 | 32 | 5 | 4.5 | 49 | 4 | -1 |
| FDG PET: diminished activity at the level of the left temporal lobe and left frontal lobe | |||||||||||
| 13 | 5 | MRI: Atrophy in left parietal and inferior temporal regions | 55 | 9 | 41 | 84 | 9 | 84.6 | 49 | 4 | -5 |
| EEG: Normal | |||||||||||
| 14 | 9 | MRI: Unremarkable | 3 | 6 | 26 | 38 | 5 | 45.4 | 40 | 6 | -8 |
Abbreviations: BNT, Boston Naming Test; WAB, Western Aphasia Battery; CIR, Clinician's Insight Rating; FBI, Frontal Behavioral Inventory; MRI, magnetic resonance imaging; EEG, electroencephalogram; MRS, magnetic resonance spectroscopy; SPECT, single photon emission computed tomography; ND, not determined; PET, positron emission tomography; NA, not applicable.
a
Patient 9 had a clinical subdiagnosis of semantic dementia without agnosia. Other patients were not subgrouped or were considered PNFA.