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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Neurosci. 2009 Jul 1;29(26):8612–8619. doi: 10.1523/JNEUROSCI.1057-09.2009

Table 2. Deletion of Mrgprd reduces DRG neuron excitability and abolishes sensitivity to 1 mM β-alanine.

Ith = threshold current to generate one AP, determined using whole-cell patch clamp electrophysiology; n=20 GFP+ neurons per genotype. Data are presented as means ± s.e.m. P-values from paired t-tests are shown; N.S. = not significant (P>0.05).

Ith (PA) APs at Ith
Genotype Control b-alanine P-value Control b-alanine P-value
+/− 103.5 ± 17.4 70 ± 10.0 0.006 1.1 ± 0.1 3.2 ± 0.5 0.0002
−/− 183.5 ± 27.9 196 ± 29.3 N.S. 1.1 ± 0.1 0.9 ± 0.2 N.S.
P-value 0.02 0.0002