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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Pharmacol Rev. 2009 Jun 4;61(2):119–161. doi: 10.1124/pr.109.001578

Figure 3. Alignment of the predicted receptor sequence of the mouse Fpr genes.

Figure 3

The putative transmembrane domains (TM-I to -VII) are highlighted in shades. Dashes indicate gaps in sequence created for alighment purpose. Notably, there is an 8-residue insertion in the N-terminal region of Fpr-1, just before TM-I. A 3-residue insertion is found in the second extracellular loop in Fpr-1. The positively charged residues R84 and K85, found in human FPR1 and known for the interaction with fMLF, are missing from Fpr-1 and other mouse Fpr-related sequences. In its place are the non-charged residues S92 and M93. The predicted Fpr-rs5 sequence is truncated at amino acids 246, resulting in a putative protein with only 5 TMs. Fpr-rs4 encodes a protein of 323 residues with a short C-terminal tail. In Fpr-rs1, there is a 4-residue deletion in TM-IV, whereas the cloned mouse LXA4 receptor gene encodes a protein with the sequence of ARNV in its place. Polymorphisms exist in the Fpr-rs1 gene that result in amino acid substitutions at positions 3 (T/S), 8 (P/H), 13 (D/E), 16 (I/V), 222 (T/Y), 236 (F/S), 296 (I/M) and 318 (Q/P) (Takano, 1997; Gao, 1998; Wang, 2002). The highest sequence identity (81%) is found between Fpr-rs1 and Fpr-rs2, and between Fpr-rs3 and Fpr-rs4.