TABLE I.

Patient demographics and cognitive scores

Measures	CTL	MCI	AD
Number of subjects	35 (13 M/22 F)	51 (30 M/21 F)	24 (10 M/14 F)
Age (years)	75.9 ± 4.6	74.1 ± 8.0 (NS)	74.8 ± 9.2 (NS)
Baseline CDR-SB	0.0 ± 0.0	1.66 ± 0.86**	4.1 ± 1.53**
Change in CDR-SB	0.057 ± 0.21	1.03 ± 1.52**	1.04 ± 1.19**
Baseline ADAS-Cog	5.05 ± 2.45	11.7 ± 4.39**	17.7 ± 5.66**
Change in ADAS-Cog	0.18 ± 2.85	2.43 ± 5.27*	3.29 ± 5.01**
Baseline MMSE	29.3 ± 0.80	26.6 ± 2.0**	22.6 ± 1.96**
Change in MMSE	–0.06 ± 1.31	–1.18 ± 2.90*	–0.96 ± 3.81 (NS)

Two-sample t-tests show which measures differed from those in controls: (NS) denotes not significant.

^*P < 0.05

^**P < 0.01.

Two-tailed tests were used to test for age differences; one-tailed tests were used for cognitive scores and changes, on the premise that scores would be expected to be poorer and declines greater in AD and MCI than in controls.