TABLE 2.

Analysis of Factors Associated with Detection of NVP Resistance in Infants at 6–8 Weeks of Age^a Four Studies, Uganda

	Resistance detected by ViroSeqb			Resistance detected by LigAmpc
Predictor variable	N	Odds ratio (95% CI)	p value	N	Odds ratio (95% CI)	p value
Maternal pre-NVP viral load (per log10 increase in HIV RNA)	71	1.06 (0.5–2.3)	0.89	64	0.98 (0.4–2.2)	0.95
Maternal pre-NVP CD4 cell count (per decrease of 100 cells/µl)	77	1.15 (0.9–1.4)	0.20	69	1.15 (0.9–1.4)	0.21
Infant viral load at 6–8 weeks (per log10 increase in HIV RNA)d	41	1.65 (0.7–4.1)	0.28	37	1.49 (0.6–4.7)	0.21
HIV subtype (D vs. A)e	65	1.51 (0.6–4.2)	0.42	62	1.15 (0.4–3.2)	0.79
HIV subtype (D vs. non-D)e	80	1.70 (0.7–4.4)	0.28	72	1.45 (0.5–3.9)	0.46
Infant sex (male vs. female)	80	0.50 (0.2–1.2)	0.13	72	0.65 (0.3–1.7)	0.37
Diagnosed with HIV infection at birth (yes/no)	80	3.50 (1.3–9.4)	0.013	72	3.90 (1.3–11.4)	0.015

^aUnivariate logistic regression models were used for analysis. Infants were enrolled in four studies (see Table 1).

^bResistance detected by ViroSeq indicates detection of one or more NVP resistance mutation (A98G, L100I, K101E/P, K103N/S, V106A/M, Y181C/I/V, Y188C/H/L, G190A/S/C/E/Q/T/V, M230L, K103R+V179D).

^cLigAmp testing was performed to detect K103N, Y181C, and G190A; resistance detected by LigAmp indicates detection of one or more of these three mutations.

^dViral load testing was performed at 6–8 weeks for infants in HIVNET 012, the Breast Feeding study, and the SWEN study; viral load testing was not performed at 6–8 weeks for infants in the Repeat Pregnancy study.

^eAmong the 80 infants who had HIV subtype data, 41 had subtype A, 4 had subtype C, 24 had subtype D, and 11 had intersubtype recombinant HIV.