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. Author manuscript; available in PMC: 2010 Feb 5.
Published in final edited form as: J Neurosci. 2009 Aug 5;29(31):9740–9747. doi: 10.1523/JNEUROSCI.2300-09.2009

Figure 2. Reduced cerebellar outflow in dystonia gene carriers.

Figure 2

A. Two dimensional (2D) projections of the group mean probabilistic connectivity tracts (PCTs; see Materials and Methods) generated from seed masks a and b (Figure 1) in normal control subjects (NL, n = 8), and in non-manifesting (NM, n = 8) and manifesting (MAN, n = 12) dystonia mutation carriers. Reduced fiber tract integrity is evident in the proximal portion of the cerebellar outflow pathway in the NM and MAN groups.

B. Box-and-whisker plot showing connectivity values for cluster a1 (Figure 1) in the proximal portion of the CbTC pathway. Connectivity in this region, corresponding to dentato-thalamic projections, was abnormally reduced in both MAN and NM gene carriers (p < 0.001 and p < 0.01, Mann-Whitney U tests). A significant decreasing trend (NL > NM > MAN, bold lines) was detected across the three groups (p < 0.001, J–T test of trends).