A. Three dimensional (3D) displays of the group mean probabilistic connectivity tracts (PCTs) generated from seed masks c and d (Figure 1) in normal control subjects (NL, n = 8), and in non-manifesting (NM, n = 8) and manifesting (MAN, n = 12) dystonia mutation carriers. The size of this fiber tract is reduced distally, most pronounced in the non-manifesting carriers.
B. Box-and-whisker plots showing connectivity values for cluster c2 (Figure 1) in the distal portion of the CbTC pathway. Connectivity in this region, corresponding to thalamo-cortical projections, was reduced in NM carriers relative to controls (p=0.016) and MAN carriers (p = 0.025, Mann-Whitney U tests). A significant trend (NL > MAN > NM, bold lines) was detected across the three groups (p = 0.001, J–T test of trends).