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. Author manuscript; available in PMC: 2010 Feb 5.
Published in final edited form as: J Neurosci. 2009 Aug 5;29(31):9740–9747. doi: 10.1523/JNEUROSCI.2300-09.2009

Figure 4. Reduced thalamo-cortical connectivity in non-manifesting dystonia gene carriers.

Figure 4

A. Three dimensional (3D) displays of the group mean probabilistic connectivity tracts (PCTs) generated from seed masks c and d (Figure 1) in normal control subjects (NL, n = 8), and in non-manifesting (NM, n = 8) and manifesting (MAN, n = 12) dystonia mutation carriers. The size of this fiber tract is reduced distally, most pronounced in the non-manifesting carriers.

B. Box-and-whisker plots showing connectivity values for cluster c2 (Figure 1) in the distal portion of the CbTC pathway. Connectivity in this region, corresponding to thalamo-cortical projections, was reduced in NM carriers relative to controls (p=0.016) and MAN carriers (p = 0.025, Mann-Whitney U tests). A significant trend (NL > MAN > NM, bold lines) was detected across the three groups (p = 0.001, J–T test of trends).