Fig. 4.
Coreceptor tropism only partially contributes to the low-producer phenotype. The frequency of infection is shown in six low producers (solid lines) and nine normally susceptible subjects (dashed lines) when infected with HIV-1LAIΔenvGFP vector pseudotyped with (A) HIV-1HXB2 or (B) HIV-1SF162, envelope. Infection with an HIV-1HXB2 pseudo-type was 1.4-fold greater in normal producers than in low producers. Infection with HIV-1SF162 pseudotype was 1.8-fold greater in normal producers than in low producers. Mean background-subtracted results are shown. The experiment was performed in duplicate and was repeated in three low producers and four normally susceptible volunteers.