Table 9.

Log-odds ratio estimates (95% confidence intervals, p-values) for gene-gene interactions between GH1 and IGF1 and between IGFBP3 and IGF1 under a log-additive model, by type of subjects included in the model.

Subjects in Model	Gene-Gene Interaction
	GH1	IGF1	GH1*IGF1
Triads	−0.14 (−0.76–0.47, 0.64)	−0.46 (−1.09–0.18, 0.16)	0.22 (−0.34–0.77, 0.44)
Triads & Dyads	−0.10 (−0.60–0.40, 0.70)	−0.30 (−0.80–0.20, 0.24)	0.24 (−0.21–0.69, 0.30)
Cases & Controls	−0.01 (−0.32–0.31, 0.98)	0.06 (−0.28–0.40, 0.74)	−0.13 (−0.46–0.21,0.46)
Triads & Controls	−0.05 (−0.36–0.27, 0.76)	−0.07 (−0.41–0.27, 0.69)	−0.03 (−0.36–0.29, 0.84)
Triads, Dyads & Controls	−0.05 (−0.36–0.26, 0.75)	−0.07 (−0.41–0.26, 0.67)	0.01 (−0.32–0.34, 0.95)
	IGFBP3	IGF1	IGFBP3*IGF1
Triads	0.70 (0.14–1.26, 0.01)	0.19 (−0.59–0.98, 0.63)	−0.33 (−0.89–0.23, 0.25)
Triads & Dyads	0.41 (−0.05–0.87, 0.09)	0.08 (−0.58–0.74, 0.81)	−0.09(−0.53–0.35, 0.67)
Cases & Controls	0.14 (−0.18–0.45, 0.39)	0.06 (−0.36–0.47, 0.78)	−0.09 (−0.40–0.24, 0.58)
Triads, Cases & Controls	0.27 (−0.04–0.57, 0.09)	0.10 (−0.29–0.50, 0.61)	−0.16 (−0.47–0.16, 0.32)
Triads, Dyads, Cases & Controls	0.22 (−0.09–0.52, 0.16)	0.07 (−0.34–0.48, 0.73)	−0.09 (−0.40–0.22, 0.55)