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. Author manuscript; available in PMC: 2010 Mar 9.
Published in final edited form as: J Neurosci. 2009 Sep 9;29(36):11377–11384. doi: 10.1523/JNEUROSCI.0969-09.2009

Figure 7. Reduced proliferation in the cerebellar anlage correlates with reduced roof plate size.

Figure 7

(A-C) Midsagittal sections of BrdU (red) and DAPI (blue) stained wild-type (A), Lmx1a−/− (B), and Lmx1a−/−; Lmx1bcko/− (C) cerebella anlage at E12.5. Arrowheads show BrdU staining in the ventricular zone. Proliferation was reduced in Lmx1a−/− and Lmx1a−/−; Lmx1bcko/− embryos.

(D) Mitotic index of E12.5 ventricular zone (BrdU/DAPI). Lmx1a−/−; Lmx1bcko/− embryos showed significant reduction compared to Lmx1a−/− embryos, which was reduced compared to wild-type embryos. * indicates p<0.01; ** indicates p<0.001. Bars indicate standard error.