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. Author manuscript; available in PMC: 2010 Mar 9.
Published in final edited form as: J Neurosci. 2009 Sep 9;29(36):11257–11262. doi: 10.1523/JNEUROSCI.2375-09.2009

Figure 1. Expression of LRRK2 transgenes in Drosophila neither affects its overall brain architecture nor triggers obvious eye abnormalities.

Figure 1

(A) Left, Anti-elav (green) and anti-LRRK2 (red) immunostaining of whole-mount adult brains derived from 2 dayold control or transgenic flies expressing wild type human LRRK2, as indicated. Right, Enlarged images (and inset) show the localization of elav and LRRK2 signals to the nucleus and cytoplasm respectively in the brain of a wild type LRRK2-expressing fly. An anti-myc immunoblot of brain lysates prepared from 2 day-old control or transgenic flies expressing various LRRK2 species is shown below (Genotype: elav-Gal4/+ or elav-Gal4-hLRRK2) (B) SEM eye images of 20 day-old GMR-Gal4/+ or GMR-Gal4-hLRRK adult flies. No retinal degeneration was observed in all flies examined.