Fig. 1.

Scanning electron microscopy analysis of teeth from Amel X^−/−, Ambn^−/−, Amel X^−/−/Ambn^−/−, wild-type mice. A. (A–D) Incisors from the 6-wk-old mutant and wild-type mice; the enamel (e) in junction with dentin (d) is shown. Note the thin aprismatic structure in Amel X^−/− mice (B). The enamel-width of Amel X^−/−/Ambn^−/− (D) mice lacks is markedly reduced as compared with that of the Ambn^−/− mice (C). B. (E–L) molars of the 6-wk-old wild-type and mutant mice; note the small crown size of Amel X^−/− mice (F) and the double mutant (H). The enamel from Amel X^−/−(F), Ambn^−/− (G) and Amel X^−/−/Ambn^−/− (H) appeared abnormal as compared to the wild-type mice (E). (I–L) Teeth from all three mutant mice mimic amelogenesis imperfecta phenotype. Amel X^−/−/Ambn^−/− enamel appeared less cobbled as compared to Ambn^−/− enamel Bars in A–D = 50 μm; bar in E–L = 250 μm. (e, enamel; d, dentin; r, resin)